I have never turned the volume past 20 (which is still I think less than half of the total max volume). I generally keep it on 12.
Just passed 5000 miles and it appears my left rear sub-woofer (up near the rear window) is blown. Unless the song I'm listening to has very little bass or I turn the bass way down via Tune - it makes terrible vibration/buzz/rattle noises.
At first I thought it was just loose and bouncing around, but accessing it from the trunk proves that it is mounted quite solidly in there so it must be blown.
Sad day. :(